Alprazolam is extensively metabolized in human beings, principally by cytochrome P450 3A4 (CYP3A4), to two big Lively metabolites in the plasma: 4-hydroxyalprazolam and ?-hydroxyalprazolam. The plasma circulation levels of The 2 active metabolites are below 4% of the parent. The noted relative potencies in benzodiazepine receptor binding experiment